Neurodegenerative disease spreading

• Talisman has previously identified the cellular mechanisms of tau exit from and entry into human neurons (Cell Reports, 2018)
• Talisman has developed a proprietary human neuron platform assay for candidate regulators of monomeric and aggregated forms of tau uptake (small molecules, peptides, antibodies)
• In-house research includes functional small molecule and genomic screens for modulators of tau entry into human neurons